Downey cells: NExt oral pathology
Downey cells, also known as Downey type II cells or atypical lymphocytes, are a type of lymphocyte that can be observed in the peripheral blood, especially during certain viral infections. These cells are often associated with infectious mononucleosis, a condition primarily caused by the Epstein-Barr virus (EBV). Here are key points about Downey cells: 1. **Appearance:** - Downey cells are large, atypical lymphocytes with irregular nuclei and abundant cytoplasm. - They may exhibit a reactive appearance, with prominent nucleoli and basophilic cytoplasm. 2. **Cell Origin:** - Downey cells are primarily activated cytotoxic T lymphocytes and B lymphocytes responding to viral infections, especially EBV. 3. **Association with Infectious Mononucleosis (IM):** - Infectious mononucleosis, commonly known as mono or glandular fever, is often characterized by the presence of Downey cells. - EBV is the most common cause of infectious mononucleosis. 4. **Clinical Features:** - Sym