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SGOT & SGPT: pathology

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SGOT (serum glutamic-oxaloacetic transaminase) and SGPT (serum glutamic-pyruvic transaminase) are two enzymes found in the liver that play a crucial role in various biochemical processes. These enzymes are commonly measured in blood tests to assess the health of the liver and other organs. Let's dive into more detail about SGOT and SGPT: **SGOT (AST - Aspartate Aminotransferase):** - **Location:** SGOT is found primarily in the liver, heart, skeletal muscles, kidneys, brain, and red blood cells. - **Function:** SGOT catalyzes the transfer of an amino group from aspartate to alpha-ketoglutarate, resulting in the formation of oxaloacetate and glutamate. This process is part of the amino acid metabolism and is involved in energy production. - **Clinical Significance:** Elevated levels of SGOT in the blood can indicate damage to liver cells (hepatocytes), heart disease (such as myocardial infarction), muscle injury, and other conditions affecting tissues where SGOT is prese