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NExt microbiology: bacteriophage Life cycle

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The lambda (λ) phase of a bacteriophage refers to the lysogenic phase in the life cycle of the bacteriophage lambda. Bacteriophage lambda, also known as λ phage, is a type of virus that infects Escherichia coli (E. coli) bacteria. The lambda phage can follow two distinct life cycles: the lysogenic cycle and the lytic cycle. The lambda phase corresponds to the lysogenic cycle of the λ phage. **Key Points about the Lambda Phase (Lysogenic Cycle):** 1. **Lysogenic Cycle:** During the lambda phase, the bacteriophage lambda enters a lysogenic cycle. In this cycle, the phage DNA becomes integrated into the bacterial host's chromosome. 2. **Prophage Formation:** The phage DNA integrated into the bacterial chromosome is called a prophage. The bacterial host containing the integrated phage DNA is referred to as a lysogen. 3. **Repressor Protein:** Once integrated, the prophage produces a repressor protein that prevents the expression of viral genes. This helps maintain a dormant