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 Letterer-Siwe disease, also known as histiocytosis X, is a rare and severe form of Langerhans cell histiocytosis (LCH). LCH is a disorder characterized by the proliferation and accumulation of abnormal Langerhans cells, a type of immune cell. Letterer-Siwe disease primarily affects children and is considered a systemic and aggressive form of LCH. Here are key features: 1. **Epidemiology:**    - Letterer-Siwe disease is most commonly diagnosed in infants and young children. 2. **Clinical Features:**    - Presents with systemic involvement, including skin rash, hepatosplenomegaly (enlargement of the liver and spleen), lymphadenopathy (enlargement of lymph nodes), and bone lesions.    - The skin rash may appear as red or purple papules or nodules. 3. **Organ Involvement:**    - Apart from skin involvement, Letterer-Siwe disease may affect multiple organs, including the liver, spleen, bone marrow, and lungs.    - Bone lesions may cause pain and deformities. 4. **Langerhans Cells:**    - A

  NEET PG 2024 As postgraduate medical aspirants gear up for the highly awaited NEET PG 2024, there's a significant twist in the tale – the tentative date has shifted to July, deviating from the traditional March schedule. This change is sending ripples through the medical community, prompting candidates to recalibrate their study plans and strategies. The National Eligibility cum Entrance Test for Postgraduate courses (NEET PG) serves as the gateway for medical graduates aiming to pursue their master's degree. Kento Yamazaki GIF from Kento Yamazaki GIFs Historically, the exam has been conducted in March, but this year, the tentative date has been pushed to July. This shift has left many candidates curious and intrigued about the reasons behind the change. One primary factor contributing to the alteration in schedule is the evolving landscape of the medical education system. The delay allows for a more comprehensive preparation time for candidates who might have f